Study of antimicrobial resistance profile and efflux mediated drug resistance in clinical isolates of Pseudomonas aeruginosa detected by ethidium bromide-agar Cartwheel method

Background: Development of antibiotic resistance or multidrug (MDR) is one the major causes treatment failure bacterial infections and has rapidly evolved into a threat to global health care. Bacterial efflux pumps play significant role in development resistance. This study evaluates prevalence pump- mediated drug clinical isolates P. aeruginosa.Methods: Clinical (n=100) aeruginosa were collected from various laboratories Kerala their detected by ethidium bromide (EB) agar Cartwheel method.Results: The EB cartwheel method screening revealed activity 17% (n=17) strains. was at minimum concentration 0 mg/l. strains showed highest up 2.5 mg/l.Conclusions: discusses emergence samples. Our results that attributable related mechanisms.